How Are Environmental Chemicals Linked to Parkinson’s Disease? How are environmental chemical exposures linked to Parkinson’s disease, and what could these connections mean for drug development? In this episode of ChatGJP, Panome Bio CSO Gary J. Patti explores emerging research on environmental chemicals and their potential role in neurodegenerative disease. The conversation also dives into […]
Discovery Exposomics profiling of 30 serum samples identified 240 exposure chemicals, with 138 showing significant differences between Alzheimer’s disease and healthy control groups. The analysis revealed distinct exposure patterns and enrichment across chemical classes, highlighting differences in the broader chemical exposome associated with Alzheimer’s disease. Explore the enrichment profile below and discover the full findings […]
Targeted Exposomics profiling of 30 serum samples revealed distinct chemical exposure patterns associated with Alzheimer’s disease. Twenty-nine chemical exposures were detected, with several showing significant differences between Alzheimer’s disease and control groups. Explore the exposure profile below and discover the full findings in the data report. This data report has been redesigned for improved clarity. […]
Metabolomic Profiling of ApoE Deficiency Reveals Altered Lipid Metabolism This application note profiles metabolic alterations associated with ApoE deficiency using matched serum and liver samples from ApoE knockout and wild-type rats. Untargeted metabolomics identified significantly altered metabolites associated with systemic lipid remodeling and disruptions in sphingolipid metabolism.
This data report profiles metabolic alterations associated with ApoE deficiency using matched serum and liver samples from ApoE knockout and wild-type rats. The study identifies significantly altered metabolites, revealing systemic lipid remodeling and disruptions in sphingolipid metabolism. The report includes metabolite identification, differential abundance analysis, pathway enrichment, and biological interpretation to characterize metabolic changes associated […]
Decoding Alzheimer’s Disease with Multi-Omics Alzheimer’s disease involves coordinated changes across metabolism, proteins and cellular systems. By combining metabolomics and proteomics, this study examines how these changes relate within the same biological context.
Alzheimer’s as a System-Level Disorder via Multi-Omics Alzheimer’s disease is not driven by a single pathway, molecule or mutation. Instead, it reflects a system-level breakdown across metabolism, protein regulation and cellular signaling. Yet most studies still analyze these layers in isolation. That’s the gap Multi-Omics is designed to close. Multi-Omics integrates complementary biological layers, such […]
This study presents an integrated proteomics and metabolomics analysis of Alzheimer’s disease using serum samples. Across 11,000+ molecular features, Panome Bio identified systemic metabolic dysregulation, lipid transport disruption, and protein-level changes associated with disease pathology.
In exposomics, there are two fundamentally different ways to explore the chemical world influencing human health and choosing the right one can make or break your study. Think of it like this: Are you searching for something specific or are you trying to discover what you don’t yet know exists? That’s the difference between targeted […]
Pinpointing the Pervasive: Exposomics Analysis of Alzheimer’s Disease This poster presents a comprehensive exposomics analysis of Alzheimer’s disease, leveraging both targeted and discovery workflows to characterize environmental exposures and their biological impact. By capturing a broad spectrum of exogenous compounds—including pollutants, dietary components, pharmaceuticals, and microbiome-derived metabolites—this work highlights the critical role of the exposome […]