Panome Bio’s advanced multi-omic technology offer unparalleled insights for animal model studies, helping you to understand disease mechanisms, evaluate therapeutic interventions, and identify novel biomarkers. Our services provide a comprehensive view of biological systems, from small molecule metabolites to complex proteins, and can integrate these layers for a deeper, more mechanistic understanding.
Identify and characterize specific metabolic changes arising from genetic modifications or disease conditions.
Alzheimer’s Disease Research
In a ApoE knockout study, rat models showed elevated levels of 14 different fats in both their blood and liver. This indicates widespread disruption of how the body processes fats when ApoE is missing.
IBD Research
In an Mdr1a knockout mice study, certain fatty molecules containing essential omega fatty acids were abnormally regulated. This suggests the Mdr1a gene plays a role in how the body handles these important dietary fats.
Evaluate therapeutic interventions and dietary impacts
Metabolic Disease Research
A study of Anti-mPD-1 treatment showed that obese mice had elevated markers related to abnormal cellular energy production. Treatment with amPD-1 reduced these markers, suggesting improved metabolic function.
Metabolic Health Biomarkers
Restricting methionine while maintaining a high-fat diet in mouse models affected several key metabolic processes: energy production (citric acid cycle), fat creation and breakdown, and mitochondrial function.
Gain Deep Mechanistic Insights with Integrated Multi-Omics
- Combine metabolite, protein, and trascriptional data for a holistic view of your system
- Identify more dysregulated biochemical pathways than with a single data type alone
- Link molecular changes to understand complex regulatory mechanisms
- Uncover critical shifts like the downregulation of energy metabolism pathways (glycolysis, nucleotide metabolism) as nutrient availability changes
Metabolic Disease Research
Analysis revealed that Anti-mPD-1 treatment reduced activity in the pentose phosphate pathway in obese mice—an effect not seen in normal-weight mice, helping to explain the mechanism behind the metabolic improvements observed with treatment.
Uncover the Complex Interplay Between Different Biological Molecules
- Mechanism of action clarity: reveal how therapeutic compounds affect molecular pathways across tissues
- Early biomarker discovery: Identify predictive markers of efficacy, toxicity, or disease progression before phenotypic changes occur
- Improved translational relevance: Link findings in preclinical models to human biology with greater confidence
Control vs ApoE Knockout Rats
Explore the power of metabolomics to identify metabolic dysregulation associated with ApoE knockout.
Antitumor and Metabolomic Differences in DIO Mice
Discover differences in tumor inhibition and treatment response between obese and control diet-fed mice.
Control vs Mdr1a Knockout Rats
Learn how metabolomics is applied in serum and liver samples to characterize metabolic changes in Mdr1a knockout rats.
Unlock Deeper Insights with Panome Bio
Panome Bio’s Next-Generation Metabolomics enables high-quality detection, helping you save time and resources. Go beyond simple comparisons to explore large cohorts and longitudinal studies. Our advanced platform delivers a global, qualitative view of metabolism, with powerful computational tools to make sense of complex data.
Contact us to start your project.