Panome Bio’s Next-Generation Metabolic Flux platform delivers a dynamic view of metabolism by tracking how nutrients flow through pathways in real time. Using stable isotope tracers, our platform goes beyond static profiling to reveal pathway activity, nutrient utilization, and metabolic rewiring with unmatched precision.
Advanced computation removes noise and irrelevant signals, isolating true tracer-derived metabolite features from raw data. Our computational pipeline then applies normalization, rigorous statistical analyses, and machine learning methods to accurately quantify isotopologue distributions and pathway activities. The Next-Generation Metabolic Flux platform provides powerful versatility with applications in drug mechanism studies, cancer metabolism, metabolic disease research, host–microbiome interactions, and systems biology.
Metabolic flux analysis tracks how metabolites move through pathways, revealing critical insights into disease mechanisms and treatment development.
Metabolic flux analysis tracks how metabolites move through pathways, revealing critical insights into disease mechanisms and drug development. Using stable isotope labeling experiments, we uncover how fluxes—affected by transcriptional, translational, and post-translational changes—are disrupted in disease states. Our experts will guide you in choosing the ideal stable isotope precursor and designing optimal labeling conditions to maximize your results. Our flux experiments can cover:
- Pentose phosphate pathway
- Tricarboxylic Acid Cycle & Reductive Carboxylation
- Glycolysis
- Bioprocessing
Advantages of our Metabolic Flux Offering
- Metabolic flux information helps researchers understand how compounds are are transformed through pathways. This reveals how systems respond to changes in their environment, treatment, or genetic modifications.
- Helps identify rate-limiting steps in metabolic networks, offering insights for potential therapeutic targets or metabolic engineering.
- Integration with Multi-Omics Data: Complements genomic, transcriptomic, and proteomic data, enabling a more comprehensive understanding of the cellular metabolic state.
- Metabolic flux experiments are not only useful in disease pathogenesis and drug target discovery, it is a crucial concept in bioprocessing. Understanding metabolic flux can significantly impact bioprocessing by enhancing product yield and optimizing substrate utilization.
Nutrient Contribution and Metabolic Flux Analysis of Metformin treated HEK-293T Cells
See how metabolic flux was used to investigate nutrient contribution in cell lines.
Let’s get started!
Discover the unparalleled advantages of Panome Bio’s advanced metabolomics technology. Your research project is unique and we can provide a custom experimental design to meet your goals. Whether you are investigating a specific disease model, elucidating biomarkers for diagnostics, or evaluating therapeutic targets, Panome Bio will work with you to design a tailored approach to best suit your research goals.
Ready to elevate your research? Connect with us today and transform your research with metabolomics.