Why Has Genomics Not Solved Most Chronic Diseases? Why hasn’t genomics solved most chronic diseases? In this episode of ChatGJP, Panome Bio CSO Gary J. Patti explains why genomics has provided valuable insights into health and disease, but cannot capture every factor that influences an individual’s health. While genomics has been applied at enormous population […]
How Is Multi-Omics Changing Chronic Disease Diagnosis? How is multi-omics changing the way researchers define and diagnose chronic disease? In this episode of ChatGJP, Panome Bio CSO Gary J. Patti explains how combining molecular data can provide greater resolution into the biological differences between patients and disease states. Chronic diseases can exist along a spectrum, […]
What Is the Biggest Challenge in Integrating Multi-Omics Data? How can researchers make complex multi-omics datasets work together? In this episode of ChatGJP, Panome Bio CSO Gary J. Patti explains the challenges of integrating genomics, proteomics, metabolomics, and exposomics data and why synchronization is key to extracting meaningful biological insights. Rather than analyzing each omics […]
Decoding Alzheimer’s Disease with Multi-Omics Alzheimer’s disease involves coordinated changes across metabolism, proteins and cellular systems. By combining metabolomics and proteomics, this study examines how these changes relate within the same biological context.
Alzheimer’s as a System-Level Disorder via Multi-Omics Alzheimer’s disease is not driven by a single pathway, molecule or mutation. Instead, it reflects a system-level breakdown across metabolism, protein regulation and cellular signaling. Yet most studies still analyze these layers in isolation. That’s the gap Multi-Omics is designed to close. Multi-Omics integrates complementary biological layers, such […]
This study presents an integrated proteomics and metabolomics analysis of Alzheimer’s disease using serum samples. Across 11,000+ molecular features, Panome Bio identified systemic metabolic dysregulation, lipid transport disruption, and protein-level changes associated with disease pathology.
The Multi-Omics Imperative in Modern Biology Complex diseases, therapeutic responses, and biological phenotypes rarely result from perturbations in single molecular pathways. Instead, they emerge from intricate interactions spanning genes, transcripts, proteins, and metabolites working in concert across interconnected biochemical networks. While individual omics approaches provide valuable insights into specific molecular layers, they inherently offer incomplete […]
ChatGJP: LC-MS Proteomics, Multi-Omics, & Precision Medicine In this episode of the ChatGJP series, Panome Bio CSO Dr. Gary J. Patti discusses the strengths and limitations of LC–MS–based proteomics compared to affinity-based approaches, highlighting why mass spectrometry remains the gold standard for unbiased protein measurement and proteoform resolution. Gary also illustrates the power of multi-omics […]
Integrated Multi-Omic Analysis of KRAS-Driven Colorectal Cancer This poster presents an integrated multi-omic analysis of colorectal cancer models driven by the KRAS mutation. By combining global metabolomics, proteomics, phosphoproteomics, and transcriptomics, the study reveals critical metabolic dependencies and pathway-level vulnerabilities associated with altered KRAS activity. The findings highlight modules of dysregulation related to EGFR signaling, […]
ChatGJP: Insights from Gary Patti on Mass Spec and Multi-Omics In this episode of the ChatGJP series, Panome Bio CSO Gary Patti shares candid insights into his research at Washington University in St. Louis, his work with Panome Bio, and the evolving landscape of mass spectrometry. Gary also explores how multi-omics technologies are transforming population-level […]