What is Metabolic Flux?
Metabolic flux is the transformation of a metabolite through a pathway. Fluxes are dysregulated in disease states, so understanding them provides actionable insights into pathogenesis and treatment development.
Our metabolomics experts will help you select the properly labeled stable isotope precursor for your experiment and design the isotope labeling conditions to produce the most meaningful results.
With the information gained from a metabolic flux experiment, you can:
- Discover drug and therapeutic targets
- Determine nutrient contribution
- Evaluate metabolic fates
- Optimize bioprocessing systems
- Ultimately, go from discovery to mechanism
Our Isotope Tracing Offerings:
- Pentose phosphate pathway
- Tricarboxylic acid cycle and reductive carboxylation
- Fatty acid synthesis and pyruvate carboxylase
- Glycolysis
Frequently Asked Questions
What is metabolic flux analysis?
Metabolic flux analysis measures the transformation of metabolites through a biochemical pathway using stable isotope tracing, revealing how pathway activity changes in disease states.
What isotope tracing offerings does Panome Bio provide?
Panome Bio offers isotope tracing across the pentose phosphate pathway, the tricarboxylic acid (TCA) cycle and reductive carboxylation, fatty acid synthesis and pyruvate carboxylase, and glycolysis.
What can a metabolic flux experiment reveal?
Metabolic flux experiments can help discover drug and therapeutic targets, determine nutrient contribution, evaluate metabolic fates, optimize bioprocessing systems, and move research from discovery to mechanism.
How does Panome Bio design stable isotope labeling studies?
Panome Bio’s metabolomics experts help select the appropriate labeled stable isotope precursor and design isotope labeling conditions tailored to produce the most meaningful results for your experiment.