Cell Surface Membrane Lipidomics Services for Translational Research

Cell Surface Membrane Lipidomics for Membrane Biology Studies

Map the lipid architecture of the cell surface with Panome Bio’s Cell Surface Membrane Lipidomics. The lipid composition of the cell membrane is a highly dynamic, active regulatory layer. Cholesterol- and sphingolipid-enriched microdomains, known as lipid rafts, selectively recruit and exclude membrane proteins, controlling receptor clustering, signal transduction, and endocytic trafficking. Conventional lipidomics performed on whole-cell extracts averages across all intracellular membranes, obscuring the biology that matters most at the cell surface.

Panome Bio’s Cell Surface Membrane Lipidomics service enriches specifically for the membrane fraction before lipid extraction, ensuring that the profiles generated reflect the lipid environment at the cell surface interface rather than the bulk cellular lipidome. Untargeted LC-MS acquisition modes enable broad structural class coverage, and our proprietary computational pipeline delivers high-confidence lipid identifications with high precision.

Advantages of Cell Surface Membrane Lipidomics:

• Membrane-fraction enrichment resolves cell surface lipid composition from intracellular compartments, providing biological specificity unavailable from whole-cell lipidomics.
• Broad structural lipid class coverage including glycerophospholipids, sphingolipids, sterol lipids, glycerolipids, prenol lipids, and fatty acyl species.
• High-confidence lipid identification powered by our computational identification pipeline, minimizing false discoveries in untargeted datasets.
• Directly interpretable in the context of membrane microdomain biology, lipid–protein coupling, and therapeutically relevant lipid antigens such as gangliosides and phosphoinositides.
• Data delivered with full statistical outputs, lipid class summaries, and publication-ready visualizations.