Cell Surface Proteomics Services
for Translational Research

Cell Surface Proteomics for Drug Discovery and Translational Research

Resolve the receptors, transporters, and signaling molecules that define the cell surface with Panome Bio’s Cell Surface Proteomics. The cell surface proteome is the primary interface through which cells communicate, respond to their environment, and engage with therapeutics. Membrane proteins — including single-pass receptors, multi-pass transporters, GPI-anchored proteins, and adhesion molecules — represent the most clinically actionable class of drug targets, yet they are systematically underrepresented in conventional proteomic workflows optimized for soluble proteins.

Panome Bio’s Cell Surface Proteomics service addresses this gap through dedicated membrane fraction enrichment prior to bottom-up proteomics sample preparation. Detected proteins are then filtered against the Surface Protein Annotation Tool (SPAT) database, retaining only proteins with strong multi-source evidence for cell surface localization and removing intracellular membrane contaminants. The result is a high-confidence map of the cell surface proteome ready for differential analysis, target prioritization, and biological interpretation.

Advantages of Cell Surface Proteomics:

• Membrane enrichment followed by SPAT-based surface protein filtering delivers a high-confidence cell surface proteome, free from intracellular membrane contamination.
• Broad topology class coverage including single-pass receptors, multi-pass transporters and channels, GPI-anchored proteins, peripheral membrane proteins, and secreted and ECM-associated proteins.
• Directly actionable for drug target and therapeutic antigen prioritization, including ADC targets, CAR-T antigens, and immune checkpoint candidates.
• Data delivered with full differential analysis outputs, surface protein annotations, and publication-ready visualizations.