Solving SAM and MTA Measurement with Isotope Standards
Measuring the Unmeasurable The most critical metabolites in PRMT5 research are also the most challenging to measure accurately. S-adenosylmethionine (SAM) and methylthioadenosine (MTA) are essential for understanding PRMT5 biology, but their inherent chemical...
Why MTAP Alone Falls Short for PRMT5 Patient Selection
Why Genetic Biomarkers Aren’t Enough for PRMT5 Patient Selection The PRMT5 inhibitor field is facing a patient selection crisis that’s quietly undermining billion-dollar drug development programs. While genomic biomarkers promised to revolutionize...