How Does Proteomics Complement Genomics in Understanding Disease?
How does proteomics complement genomics in understanding disease? While genomics provides information about an individual’s genetic makeup and potential disease risk, proteomics offers a closer look at what is actually happening inside cells.
In this episode of ChatGJP, Gary J. Patti, CSO of Panome Bio, explains how genomics and proteomics capture different levels of biological information. Genes sit near the beginning of the genotype-to-phenotype cascade, providing the instructions for producing proteins. Proteomics measures those proteins downstream, providing insight into their abundance, activity, and functional state. Gary also discusses how advanced proteomics can characterize proteoforms, splice variants, and post-translational modifications such as phosphorylation, providing additional insight into the molecular mechanisms underlying health and disease.
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