News & Events / Events / Integrated multi-omics unlocks holistic phenotypic insights allowing for deep molecular exploration

Integrated multi-omics unlocks holistic phenotypic insights allowing for deep molecular exploration

The omics era has greatly expanded the repertoire of approaches available for researchers and clinicians to unravel the complexity underpinning human health: Next Generation Sequencing (NGS) and Mass Spectrometry (MS) approaches can characterize genomes, epigenomes, transcriptomes, proteomes and metabolomes. Advanced DNA barcoding and automated microfluidics can take this to the next level, enabling multiomic characterization of single cells. Peripheral blood mononuclear cells (PBMCs) offer a non-invasive approach that, when combined with omics tools, can provide a near holistic view of immune processes across patient cohorts.

Here we detail a proof-of-principle workflow which utilizes a single blood draw to rapidly produce a diverse set of multiomics results including genomics, epigenomics, transcriptomics, proteomics and metabolomics.

With over a decade of experience with multiomics technologies, Dr. Andrea O’Hara guides technological innovations and life-cycle management at Azenta. She earned her Ph.D. from the University of North Carolina at Chapel Hill in genetics and molecular biology and a B.A. in biology from The John Hopkins University. Dr. O’Hara completed her postdoctoral training at the National Institutes of Health, focusing on genomic alterations in various endometrial cancers.