This webinar, featuring Dr. Andrew Patterson of Penn State University, will explore how metabolomics is advancing our understanding of host–microbiome interactions, with a special focus on bile acids. Traditionally recognized for their role in fat solubilization, bile acids are now emerging as powerful biomarkers of microbiome function and versatile signaling molecules with diverse biological roles. Dr. Patterson will highlight the discovery of novel bile acid conjugates and new molecular targets, underscoring how multi-omic approaches are essential to unraveling the complex dialogue between host and microbiome.