Advanced Microbiome Analysis with Next-Generation Metabolomics
Panome Bio offers a comprehensive microbiome function analysis that measures bile acids and short chain fatty acids (SCFAs), plus a global metabolomics screen for the broadest coverage and advanced understanding of the role of the microbiome in health and disease. Panome Bio also offers a multi-omics approach through integration of microbiome sequencing data with metabolomics. Integration of transcriptomics and metabolomics data can be used to identify gene-metabolite relationships, understand metabolic pathways, understand cellular response and mechanism of disease, and discover novel biomarkers and drug targets.
Global Metabolomics
- Important molecules measured include amino acids, sugars, nucleotides, nucleosides, and energy metabolites, among many others.
Bile Acid Assay
- Primary Bile Acids
- HumanCholic acid (CA); Chenodeoxycholic acid (CDCA); Glycine-CA; Glycine-CDCA; Taurine-CA
- Mousealpha/beta-Muricholic acid (a/b-MCA); omega-Muricholic acid (o-MCA); Gly-a/b-MCA; Taur-a/b-MCA
- Secondary Bile Acids
- Host-ConjugatedDeoxycholic acid (DCA); Lithocholic acid (LCA)
- FreeGlycine-DCA; Glycine-LCA
- Bile Acid Amidates
- BackboneGroup
- Chenodeoxycholic acidCysteine; Glutamic acid; Histidine; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Tryptophan; Tyrosine
- Cholic acidAlanine; Arginine; Glutamic acid; Isoleucine; Leucine; Phenylalanine; Tryptophan; Tyrosine
- Deoxycholic acidGlutamic acid; Isoleucine; Leucine; Lysine; Methionine; Tryptophan; Tyrosine
- Hyocholic acidGlutamic acid
- Hyodeoxycholic acidGlutamic acid; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Tryptophan; Tyrosine
- Ursodeoxycholic acidGlutamic acid; Glutamine; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Tryptophan; Tyrosine
- Additional Bile Acids
- Hyocholic acid; Hyodeoxycholic acid; Ursodeoxycholic acid ; 3-Ketocholanic acid; Lithocholenic acid; 3b-Hydroxy-5-cholenoic acid; 8(14),(5β)-Cholenic acid-3α, 12α-diol; 5-β-Cholanic acid-3α-ol-6-one; Isolithocholic acid; Isodeoxycholic acid; 9(11), (5β)-Cholenic acid-3α-ol-12-one; 5α-Cholanic acid-3, 6-dione; 3,7-Dioxocholanic acid; 3,6-Dioxocholanic acid
Short Chain Fatty Acids (SCFAs)
- Short Chain Fatty Acids
- Butyrate, Isobutyrate
- 2-Hydroxybutryate (2-HB), 3-Hydroxybutryate (3-HB), 4-Hydroxybutryate (4-HB), 3-Hydroxyisobutyrate (3-HIB), 2-Methylbutyrate
- Caproate, Isocaproate, alpha-Ketoisocaproate (a-KIC)
- Valerate, Isovalerate, alpha-Ketoisovalerate (a-KIV), alpha-Ketomethylvalerate (a-KMV)
- Acetate, Acetone, Acetoacetate (AcAc)
- Propionate
Frequently Asked Questions
How is the microbiome analyzed using metabolomics?
Panome Bio measures bile acids and short chain fatty acids (SCFAs) alongside a global metabolomics screen to capture the broadest possible view of microbiome-related metabolic activity.
What are bile acids and SCFAs, and why are they measured?
Bile acids and short chain fatty acids are key molecules produced through microbiome metabolism that influence host health, making them important markers for understanding the microbiome’s role in disease.
Can microbiome metabolomics be integrated with sequencing data?
Yes. Panome Bio offers a multi-omics approach that integrates microbiome sequencing data with metabolomics to identify gene-metabolite relationships and metabolic pathways.
What can microbiome multi-omics analysis reveal?
It can help identify gene-metabolite relationships, clarify metabolic pathways and cellular response, and support discovery of novel biomarkers and drug targets related to microbiome health.