Decoding Natural Product Biosynthesis with Metabolomics
The discovery and development of natural products continues to represent a cornerstone of pharmaceutical innovation, yet traditional bioactivity-guided fractionation approaches increasingly yield diminishing returns as researchers encounter the rediscovery problem....
The SDMA and ADMA Measurement Challenge
Why Accurate SDMA and ADMA Measurement Is Essential for PRMT5 Inhibitors The protein arginine methyltransferase (PRMT) field has a measurement problem that’s quietly undermining drug development programs across the industry. While symmetric dimethylarginine...
Unbiased Proteomics for Molecular Glue Target Discovery
Phenotypic Screening and Target Deconvolution for Molecular Glue Discovery Molecular glue degraders represent a unique class of therapeutic compounds that modify E3 ligase substrate specificity to induce targeted protein degradation. Unlike PROTACs, which require...