The SDMA and ADMA Measurement Challenge
Why Accurate SDMA and ADMA Measurement Is Essential for PRMT5 Inhibitors The protein arginine methyltransferase (PRMT) field has a measurement problem that’s quietly undermining drug development programs across the industry. While symmetric dimethylarginine...
Unbiased Proteomics for Molecular Glue Target Discovery
Phenotypic Screening and Target Deconvolution for Molecular Glue Discovery Molecular glue degraders represent a unique class of therapeutic compounds that modify E3 ligase substrate specificity to induce targeted protein degradation. Unlike PROTACs, which require...
Is Your mRNA Making the Right Protein? Proteomics Reveals It
The Assumption That Derails Programs The promise of mRNA therapeutics is elegant: deliver genetic instructions, let cells produce therapeutic proteins, and bypass traditional drug manufacturing. But there’s a critical gap between mRNA design and therapeutic...