Mapping Signaling Drivers of Antibody Drug Conjugate Resistance
Antibody-drug conjugate (ADC) resistance represents one of the most formidable challenges in precision oncology, with clinical failures often attributed to our limited understanding of the dynamic molecular mechanisms underlying therapeutic escape. Panome Bio’s...
A Metabolic Blueprint for Synergistic Cancer Therapy
In the fight against cancer, single-agent treatments often hit a wall as tumors adapt and develop resistance. This is especially true for aggressive cancers like non-small-cell lung cancer (NSCLC) with KRAS and LKB1 mutations, a hard-to-treat subtype. These challenges...
Multi-Omics in Animal Models for Preclinical Discovery
Animal models have long been the cornerstone of biomedical research. They provide scientists with an invaluable window into disease mechanisms, treatment responses, and the intricate biology that drives health and illness. Yet, as research questions grow more complex,...