The Future of PROTAC Research: Emerging Opportunities and Challenges
Proteolysis Targeting Chimeras (PROTACs) have fundamentally transformed our approach to targeted therapeutics, offering a paradigm shift from traditional protein inhibition to selective protein degradation. These hetero-bifunctional molecules hijack the ubiquitin...
FFPE Metabolomics: A New Dimension in Multi-Omics and Precision Medicine
In translational research today, multi-omics is no longer a concept — it’s an expectation. Genomics and transcriptomics reveal what could happen; proteomics shows what is happening at the protein level; and metabolomics offers the most immediate snapshot of cellular...
Novel PROTAC Technologies: Advancing Targeted Protein Degradation Through Innovative Conjugation Strategies
Proteolysis-targeting chimeras (PROTACs) have emerged as a transformative approach in drug discovery, offering event-driven protein degradation mechanisms that overcome limitations of traditional occupancy-driven inhibitors. While conventional small-molecule PROTACs...