Improving ADC Research via Surface Proteomics
Antibody-drug conjugates (ADCs) represent a paradigm shift in targeted cancer therapy, combining the specificity of monoclonal antibodies with the cytotoxic potency of small molecule drugs through sophisticated linker chemistry. Despite remarkable clinical successes...
Future of PROTAC Research: Opportunities and Obstacles
Proteolysis Targeting Chimeras (PROTACs) have fundamentally transformed our approach to targeted therapeutics, offering a paradigm shift from traditional protein inhibition to selective protein degradation. These hetero-bifunctional molecules hijack the ubiquitin...
FFPE Metabolomics to Multi‑Omics and Precision Medicine
In translational research today, multi-omics is no longer a concept — it’s an expectation. Genomics and transcriptomics reveal what could happen; proteomics shows what is happening at the protein level; and metabolomics offers the most immediate snapshot of cellular...