Panome Bio’s Next-Generation Metabolomics analysis of Mdr1a KO rats revealed substantial dysregulation of many core metabolic processes, including lipid and nucleotide metabolism. These metabolic changes should be considered when analyzing metabolic effects of therapeutics that interact with Mdr1a and other drug efflux transporters.

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Next-Generation Metabolomics: Metabolic Effects of MDR1 Inhibition

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