Next-Generation Metabolic Flux Analysis | Panome Bio

Metabolic Flux: Tracking Pathways in Action

Metabolic flux is the transformation of a metabolite through a pathway. Tracking pathways in action is possible with stable isotope labeling experiments. Metabolic fluxes correlate to regulation at the transcriptional, translational, post-translational and protein-metabolite interaction level. Fluxes are dysregulated in disease states, so understanding them provides actionable insights into pathogenesis and treatment development.

Our metabolomics experts will help you select the properly labeled stable isotope precursor for your experiment and design the isotope labeling conditions to produce the most meaningful results.

Contact us to plan your isotope tracing experiments today!

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Our Isotope Tracing Offerings

Pentose Phosphate Pathway

The pentose phosphate pathway (PPP) plays a vital role in cellular metabolism. Its dysregulation contributes various diseases, including cancer, neurodegenerative diseases, metabolic disorders, and cardiovascular diseases.

Tricarboxylic Acid Cycle & Reductive Carboxylation

The TCA cycle, also know as the tricarboxylic acid cycle or the citric acid cycle, is a central metabolic pathway that occurs in the mitochondria of eukaryotic cells and is involved in cellular respiration. Reductive carboxylation is a novel pathway of glutamine metabolism that plays a role in many types of cancer.

Fatty Acid Synthesis & Pyruvate Carboxylase

The pyruvate carboxylase pathway is an important mechanism that allows cells to efficiently utilize pyruvate and integrate multiple metabolic pathways for energy production, glucose homeostasis, and biosynthesis.


Glycolysis is a fundamental metabolic pathway that occurs in the cytoplasm of cells and is responsible for the breakdown of glucose into pyruvate, generating ATP in the process.
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