Oncology

Oncometabolomics for Biomarker
Discovery and Disease Diagnosis

Oncometabolomics is a field of study that focuses on the analysis of the metabolic changes that occur in cancer cells. It aims to identify new biomarkers and therapeutic targets for cancer. With Panome Bio’s Next-Generation Metabolomics platform, you can discover new biomarkers, evaluate therapeutic targets and get valuable insights to the phenotype of disease.

Gain-of-function mutations in is-citrate dehydrogenase 1 (IDH1) occur in multiple types of cancer. These mutations
result in the enzyme producing the oncometabolite, 2-hydroxygulutarate, which leads to the formation of cancer.

Case Study

A metabolomics study found that the oncometabolite 2-hydroxyglutarate (2-HG) is produced at high levels in glioma cells harboring gain of function mutation in isocitrate dehydrogenase (IDH), which is an enzyme in the citric acid cycle.

Inhibiting the enzyme that produces 2-HG reduce the growth of glioma cells, indicating that targeting 2-HG production may be an effective therapeutic strategy for glioma.

Visit our resources section for more information on Panome Bio’s applications in oncology!

Protein Name	UniProt Accession Number
78 kDa glucose-regulated protein	P11021
Adipocyte plasma membrane-associated protein	Q9HDC9
Adiponectin	Q15848
Afamin	P43652
Alpha-1-acid glycoprotein 1	P02763
Alpha-1-antichymotrypsin	P01011
Alpha-1-antitrypsin	P01009
Alpha-1B-glycoprotein_VAR_018369	P04217
Alpha-2-antiplasmin	P08697
Alpha-2-HS-glycoprotein	P02765
Alpha-2-macroglobulin	P01023
Antithrombin-III	P01008
Apolipoprotein A-I	P02647
Apolipoprotein A-II	P02652
Apolipoprotein A-IV	P06727
Apolipoprotein B-100	P04114
Apolipoprotein C-I	P02654
Apolipoprotein C-II	P02655
Apolipoprotein C-III	P02656
Apolipoprotein C-IV	P55056
Apolipoprotein D	P05090
Apolipoprotein E	P02649
Apolipoprotein L1	O14791
Apolipoprotein M	O95445
Apolipoprotein(a)	P08519
Attractin	O75882
Beta-2-glycoprotein 1	P02749
Beta-Ala-His dipeptidase	Q96KN2
Biotinidase	P43251
Cadherin-13	P55290
Carbonic anhydrase 1	P00915
Carboxypeptidase B2	Q96IY4
Cathelicidin antimicrobial peptide	P49913
Cation-independent mannose-6-phosphate receptor	P11717
CD5 antigen-like	O43866
Ceruloplasmin	P00450
Cholinesterase	P06276
Clusterin	P10909
Coagulation factor IX	P00740
Coagulation factor V	P12259
Coagulation factor VIII	P00451
Coagulation factor X	P00742
Coagulation factor XII	P00748
Complement C1q subcomponent subunit B	P02746
Complement C1q subcomponent subunit C	P02747
Complement C1r subcomponent	P00736
Complement C1r subcomponent-like protein	Q9NZP8
Complement C1s subcomponent	P09871
Complement C2	P06681
Complement C3	P01024
Complement C5	P01031
Complement component C7	P10643
Complement component C9	P02748
Complement factor B	P00751
Complement factor H	P08603
Complement factor I	P05156
Corticosteroid-binding globulin	P08185
Cystatin-C	P01034
Endothelial protein C receptor	Q9UNN8
Fetuin-B	Q9UGM5
Fibrinogen alpha chain	P02671
Fibrinogen beta chain	P02675
Fibrinogen gamma chain	P02679
Fibronectin	P02751
Fibulin-1	P23142
Galectin-3-binding protein	Q08380
Gelsolin	P06396
Glutathione peroxidase 3	P22352
Haptoglobin	P00738
Hemoglobin subunit alpha	P69905
Hemopexin	P02790
Heparin cofactor 2	P05546
Hepatocyte growth factor-like protein	P26927
Hyaluronan-binding protein 2	Q14520
Ig mu chain C region	P01871
Insulin-like growth factor I	P05019
Inter-alpha-trypsin inhibitor heavy chain H2	P19823
Intercellular adhesion molecule 1	P05362
Interleukin-10	P22301
Kallistatin	P29622
Keratin type I cytoskeletal 10	P13645
Keratin-type II cytoskeletal 2 epidermal	P35908
Kininogen-1	P01042
Leucine-rich alpha-2-glycoprotein	P02750
Lipopolysaccharide-binding protein	P18428
L-selectin	P14151
Lysozyme C	P61626
Mannan-binding lectin serine protease 1	P48740
Mannan-binding lectin serine protease 2	O00187
Metalloproteinase inhibitor 2	P16035
Myeloblastin	P24158
Peroxiredoxin-2	P32119
Phosphatidylinositol-glycan-specific phospholipase D	P80108
Phospholipid transfer protein	P55058
Pigment epithelium-derived factor	P36955
Plasma protease C1 inhibitor	P05155
Plasma serine protease inhibitor	P05154
Plasminogen	P00747
Plasminogen activator inhibitor 1	P05121
Pregnancy zone protein	P20742
Protein AMBP	P02760
Protein S100-A9	P06702
Protein Z-dependent protease inhibitor	Q9UK55
Prothrombin	P00734
Retinol-binding protein 4	P02753
Serotransferrin	P02787
Serum albumin	P02768
Serum paraoxonase/arylesterase 1	P27169
Serum paraoxonase/lactonase 3	Q15166
SPARC	P09486
Tenascin	P24821
Tenascin-X	P22105
Thrombospondin-1	P07996
Thrombospondin-4	P35443
Thyroxine-binding globulin	P05543
Tissue factor pathway inhibitor (isoform 1)	P10646
Tissue-type plasminogen activator	P00750
Transferrin receptor protein 1	P02786
Transthyretin	P02766
Vascular cell adhesion protein 1	P19320
Vasorin	Q6EMK4
Vitamin K-dependent protein S	P07225
Vitamin K-dependent protein Z	P22891
Vitronectin	P04004
Zinc-alpha-2-glycoprotein	P25311

Applications

Oncometabolomics for Biomarker
Discovery and Disease Diagnosis

Advance CAR T Cell Research with Metabolomics

With data from Panome Bio,
gain insights to oncology research:

Case Study

Contact Us

Reach out today to learn more about our Next-Generation Metabolomics™ offerings!

Protein Name	UniProt Accession Number
Adiponectin	Q60994
Afamin	O89020
Alpha-1-acid glycoprotein 2	P07361
Alpha-1-antitrypsin 1-1	P07758
Alpha-1-antitrypsin 1-4	Q00897
Alpha-1B-glycoprotein	Q19LI2
Alpha-2-antiplasmin	Q61247
Alpha-enolase	P17182
Angiotensinogen	P11859
Antithrombin-III	P32261
Apolipoprotein A-II	P09813
Apolipoprotein A-IV	P06728
Apolipoprotein C-IV	Q61268
Apolipoprotein D	P51910
Apolipoprotein M	Q9Z1R3
Bisphosphoglycerate mutase	P15327
BPI fold-containing family A member 2	P07743
Cadherin-5	P55284
Carbonic anhydrase 2	P00920
Carboxypeptidase B2	Q9JHH6
Carboxypeptidase N catalytic chain	Q9JJN5
Carboxypeptidase Q	Q9WVJ3
Cartilage oligomeric matrix protein	Q9R0G6
Cathepsin D	P18242
CD5 antigen-like	Q9QWK4
Ceruloplasmin	Q61147
Coagulation factor V	O88783
Coagulation factor X	O88947
Coagulation factor XII	Q80YC5
Coagulation factor XIII A chain	Q8BH61
Coagulation factor XIII B chain	Q07968
Collagen alpha-2(I) chain	Q01149
Collectin-11	Q3SXB8
Complement C1q subcomponent subunit A	P98086
Complement C1q subcomponent subunit C	Q02105
Complement C1r subcomponent-like protein	Q3UZ09
Complement C3	P01027
Complement C4-B	P01029
Complement component C8 beta chain	Q8BH35
Complement component C8 gamma chain	Q8VCG4

Protein Name	Gene names	UniProt Accession Number	Link	Peptide Sequence	Disease	Description
60 kDa heat shock protein mitochondrial	HSPD1 HSP60	P10809	https://www.uniprot.org/uniprot/P10809	GIIDPTK	spastic paraplegia 13 autosomal, autosomal dominant	neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.
N/L	N/L	N/L	N/L	N/L	leukodystrophy neurodegeneration	A severe autosomal recessive hypomyelinating leukodystrophy. Clinically characterized by infantile-onset rotary nystagmus, progressive spastic paraplegia, neurologic regression, motor impairment, profound mental retardation.
72 KDa type IV collagenase	MMP2 CLG4A	P08253	https://www.uniprot.org/uniprot/P08253	IDAVYEAPQEEK	Multicentric osteolysis, nodulosis and arthopathy (MONA)	An autosomal recessive syndrome characterized by severe multicentric osteolysis with predominant involvement of the hands and feet.
Endoplasmic reticulum chaperone BiP	HSPA5 GRP78	P11021	https://www.uniprot.org/uniprot/P11021	ITPSYVAFTPEGER	Autoantigen in rheumatoid arthritis.	N/L
A disintegrin and metalloproteinase with thrombospondin motifs 2	ADAMTS2 PCINP PCPNI	O95450	https://www.uniprot.org/uniprot/O95450	IILLSYGK	Ehlers-Danlos syndrome, dermatosparaxis type (EDSDERMS)	A form of Ehlers-Danlos syndrome, a group of connective tissue disorders characterized by skin hyperextensibility, articular hypermobility, and tissue fragility. EDSDERMS is an autosomal recessive form characterized by extreme skin fragility and easy bruising, large fontanels, blue sclerae, puffy eyelids, micrognathia, umbilical hernia, and short fingers.
A disintegrin and metalloproteinase with thrombospondin motifs 20	ADAMTS20	P59510	https://www.uniprot.org/uniprot/P59510	IPAGATNVDIR	0	N/L
A disintegrin and metalloproteinase with thrombospondin motifs 9	ADAMTS9 KIAA1312	Q9P2N4	https://www.uniprot.org/uniprot/Q9P2N4	LYNPDVR	0	N/L
Actin, aortic smooth muscle \| Actin, alpha cardiac muscle 1 \| 8 other actin and actin-like proteins	ACTA2 ACTSA ACTVS GIG46	P62736	https://www.uniprot.org/uniprot/P62736	SYELPDGQVITIGNER	ACTA2 mutations predispose patients to a variety of diffuse and diverse vascular diseases, premature onset coronary artery disease (CAD), premature ischemic strokes and Moyamoya disease.	N/L
N/L	N/L	N/L	N/L	https://www.uniprot.org/uniprot/P62736	Aortic aneurysm, familial thoracic 6 (AAT6)	A disease characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. It is primarily associated with a characteristic histologic appearance known as ‘medial necrosis’ or ‘Erdheim cystic medial necrosis’ in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.
N/L	N/L	N/L	N/L	N/L	Moyamoya disease 5 (MYMY5)	A progressive cerebral angiopathy characterized by bilateral intracranial carotid artery stenosis and telangiectatic vessels in the region of the basal ganglia. The abnormal vessels resemble a ‘puff of smoke’ (moyamoya) on cerebral angiogram. Affected individuals can develop transient ischemic attacks and/or cerebral infarction, and rupture of the collateral vessels can cause intracranial hemorrhage. Hemiplegia of sudden onset and epileptic seizures constitute the prevailing presentation in childhood, while subarachnoid bleeding occurs more frequently in adults.
N/L	N/L	N/L	N/L	N/L	Multisystemic smooth muscle dysfunction syndrome (MSMDYS)	A syndrome characterized by dysfunction of smooth muscle cells throughout the body, leading to aortic and cerebrovascular disease, fixed dilated pupils, hypotonic bladder, malrotation, and hypoperistalsis of the gut and pulmonary hypertension.
Actin, aortic smooth muscle \| Actin, alpha cardiac muscle 1 \| 8 other actin and actin-like proteins	ACTC1 ACTC	P68032	https://www.uniprot.org/uniprot/P68032	SYELPDGQVITIGNER	1. Cardiomyopathy, dilated 1R (CMD1R)	A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
N/L	N/L	N/L	N/L	https://www.uniprot.org/uniprot/P68032	Cardiomyopathy, familial hypertrophic 11 (CMH11)	A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
N/L	N/L	N/L	N/L	N/L	Atrial septal defect 5 (ASD5}.	A congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria.
Adhesion G protein-coupled receptor F5	ADGRF5 GPR116 KIAA0758	Q8IZF2	https://www.uniprot.org/uniprot/Q8IZF2	DVIVHPLPLK	0	N/L
Adipocyte plasma membrane-associated protein	APMAP C20orf3 UNQ1869/PRO4305	Q9HDC9	https://www.uniprot.org/uniprot/Q9HDC9	LLEYDTVTR	0	N/L
Adiponectin	ADIPOQ ACDC ACRP30 APM1 GBP28	Q15848	https://www.uniprot.org/uniprot/Q15848	IFYNQQNHYDGSTGK	Adiponectin deficiency (ADPND)	condition that results in very low concentrations of plasma adiponectin.
N/L	N/L	N/L	N/L	N/L	Diabetes mellitus, non-insulin-dependent (NIDDM)	A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body’s own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
ADM	ADM AM	P35318	https://www.uniprot.org/uniprot/P35318	LDVASEFR	0	N/L
Afamin	AFM ALB2 ALBA	P43652	https://www.uniprot.org/uniprot/P43652	DADPDTFFAK	0	N/L
Alpha-1-acid glycoprotein 1	ORM1 AGP1	P02763	https://www.uniprot.org/uniprot/P02763	NWGLSVYADKPETTK	0	N/L
Alpha-1-antichymotrypsin	SERPINA3 AACT GIG24 GIG25	P01011	https://www.uniprot.org/uniprot/P01011	EIGELYLPK	0	N/L
Alpha-1-antitrypsin	SERPINA1 AAT PI PRO0684 PRO2209	P01009	https://www.uniprot.org/uniprot/P01009	SVLGQLGITK	Alpha-1-antitrypsin deficiency (A1ATD)	A disorder whose most common manifestation is emphysema, which becomes evident by the third to fourth decade. A less common manifestation of the deficiency is liver disease, which occurs in children and adults, and may result in cirrhosis and liver failure
Alpha-1B-glycoprotein_VAR_018369	A1BG	P04217	https://www.uniprot.org/uniprot/P04217	LETPDFQLFK	0	N/L
Alpha-2-antiplasmin	SERPINF2 AAP PLI	P08697	https://www.uniprot.org/uniprot/P08697	LGNQEPGGQTALK	Alpha-2-plasmin inhibitor deficiency	An autosomal recessive disorder resulting in severe hemorrhagic diathesis.
Alpha-2-HS-glycoprotein	AHSG FETUA PRO2743	P02765	https://www.uniprot.org/uniprot/P02765	FSVVYAK	Alopecia-mental retardation syndrome 1 (APMR1)	A rare autosomal recessive form of alopecia. APMR1 patients show loss of hair on the scalp, absence of eyebrows, eyelashes, axillary and pubic hair, and mild to severe mental retardation.
Alpha-2-macroglobulin	A2M CPAMD5 FWP007	P01023	https://www.uniprot.org/uniprot/P01023	AIGYLNTGYQR	0	N/L
Angiogenin	ANG RNASE5	P03950	https://www.uniprot.org/uniprot/P03950	DINTFIHGNK	Amyotrophic lateral sclerosis 9 (ALS9)	A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.
Angiopoietin-related protein 3	ANGPTL3 ANGPT5 UNQ153/PRO179	Q9Y5C1	https://www.uniprot.org/uniprot/Q9Y5C1	DLVFSTWDHK	Hypobetalipoproteinemia, familial, 2 (FHBL2)	A disorder of lipid metabolism characterized by less than 5th percentile age- and sex-specific levels of low density lipoproteins, and dietary fat malabsorption. Affected individuals present with combined hypolipidemia, consisting of extremely low plasma levels of LDL cholesterol, HDL cholesterol, and triglycerides.
N/L	N/L	N/L	N/L	N/L	May be involved in atherosclerosis.	Plasma levels are closely associated with arterial wall thickness.
N/L	N/L	N/L	N/L	N/L	May be involved in nephrotic syndrome	N/L
Angiotensinogen	AGT SERPINA8	P01019	https://www.uniprot.org/uniprot/P01019	ALQDQLVLVAAK	Essential hypertension (EHT)	A condition in which blood pressure is consistently higher than normal with no identifiable cause
N/L	N/L	N/L	N/L	N/L	Renal tubular dysgenesis (RTD)	Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
Antithrombin-III	SERPINC1 AT3 PRO0309	P01008	https://www.uniprot.org/uniprot/P01008	DDLYVSDAFHK	DISEASE: Antithrombin III deficiency (AT3D)	An important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. Antithrombin-III deficiency is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin-binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations.
Apolipoprotein A-I	APOA1	P02647	https://www.uniprot.org/uniprot/P02647	ATEHLSTLSEK	High density lipoprotein deficiency 2 (HDLD2)	Inherited as autosomal dominant trait. It is characterized by moderately low HDL cholesterol, predilection toward premature coronary artery disease (CAD) and a reduction in cellular cholesterol efflux.
N/L	N/L	N/L	N/L	N/L	High density lipoprotein deficiency 1 (HDLD1)	Recessive disorder characterized by absence of high density lipoprotein (HDL) cholesterol from plasma, accumulation of cholesteryl esters, premature coronary artery disease (CAD), hepatosplenomegaly, recurrent peripheral neuropathy and progressive muscle wasting and weakness
N/L	N/L	N/L	N/L	N/L	Amyloidosis 8 (AMYL8)	A form of hereditary generalized amyloidosis. Clinical features include extensive visceral amyloid deposits, renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. There is no involvement of the nervous system.
N/L	N/L	N/L	N/L	N/L	APOA1 mutations may be involved in the pathogenesis of amyloid polyneuropathy-nephropathy Iowa type, also known as amyloidosis van Allen type or familial amyloid polyneuropathy type III	N/L
Apolipoprotein A-II	APOA2	P02652	https://www.uniprot.org/uniprot/P02652	SPELQAEAK	0	N/L
Apolipoprotein A-IV	APOA4	P06727	https://www.uniprot.org/uniprot/P06727	LGEVNTYAGDLQK	0	N/L

Applications

Oncology

Oncometabolomics for Biomarker Discovery and Disease Diagnosis

Advance CAR T Cell Research with Metabolomics

With data from Panome Bio, gain insights to oncology research:

Case Study

Oncometabolomics for Biomarker
Discovery and Disease Diagnosis

With data from Panome Bio,
gain insights to oncology research: