Panome Bio Webinars

Enhancing Biological Discovery in
Metabolomics with Stable Isotopes

Wednesday, August 2, 2023

12PM EST | 9AM PST

Presenter: Gary J. Patti, PhD
Hosted by: Panome Bio

Metabolic flux is the rate at which a metabolite and its intermediates are transformed through biochemical pathways. Understanding metabolic fluxes provides valuable insights into pathogenesis and treatment development. In this webinar, Dr. Gary J. Patti explains metabolic flux, stable isotope tracer experiments, and how Panome Bio’s next-Generation Metabolomics™ is changing the way metabolic flux analysis is performed.

Topics Covered:

  • What is metabolic flux and why it is relevant for researchers
  • Panome Bio’s approach to metabolic flux
  • A recent case study using metabolic flux experiments in cancer cells
  • Evaluating metabolic fates with metabolic flux

Gary J. Patti, PhD, founder of Panome Bio, is a leading researcher in the field of metabolomics and a Professor at Washington University in St. Louis, where he holds appointments in the department of chemistry and the department of medicine. Dr. Patti’s research focuses on developing and applying both mass spectrometry-based and NMR-based metabolomics technologies to enhance our understanding of human health. Dr. Patti has helped advance the field of metabolomics through the development of gold-standard software tools, commercial benchmarking kits, and NIH led ring trials. Among his notable contributions is pioneering the credentialing technology to demonstrate the high prevalence of noise in metabolomics data, which is the basis for our Next-Generation Metabolomics™️ platform.

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    From Discovery to Mechanism: Direct Observations of Metabolic Pathway Activity

    Wednesday, August 9, 2023

    12 PM ET | 9AM PST

    Presenter: Adam Richardson, PhD
    Hosted by: Panome Bio

    Global metabolomics is a powerful approach to discovering which metabolites in a system change in response to different conditions or over time. These changes provide the basis for new hypotheses regarding metabolic activity and control. However, a change in the amount of a metabolite could be caused by either increased production of the compound, or by decreased consumption. In order to determine the relative activity of the metabolic enzyme or pathway we track the metabolism of stable isotope compounds through the system. The use of these safe, non-radioactive tracer compounds allow you to test the hypotheses generated by global discovery metabolomics. This webinar will describe some appropriate use cases for stable isotope tracing and provide examples of hypothesis testing.


    Adam D. Richardson, PhD, is the Study Director at Panome Bio. Dr. Richardson has previously served as Director of the NCI Cancer Metabolism Shared Service and Research Professor (Signal Transduction) at Sanford Burnham Prebys in La Jolla. His background lies at the intersection of analytical chemistry and cell biology, particularly primary and secondary metabolism. Prior to joining Panome Bio Dr. Richardson’s work focused on using stable isotope tracing to map the metabolic shifts that occur during tumor progression, characterizing small molecule therapeutics, and delivering high quality laboratory services to research partners.

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