by ODWAdmin | Sep 25, 2025 | Uncategorized
Antibody-drug conjugates (ADCs) represent a paradigm shift in targeted cancer therapy, combining the specificity of monoclonal antibodies with the cytotoxic potency of small molecule drugs through sophisticated linker chemistry. Despite remarkable clinical successes...
by ODWAdmin | Sep 24, 2025 | Uncategorized
Proteolysis Targeting Chimeras (PROTACs) have fundamentally transformed our approach to targeted therapeutics, offering a paradigm shift from traditional protein inhibition to selective protein degradation. These hetero-bifunctional molecules hijack the ubiquitin...
by ODWAdmin | Sep 22, 2025 | Uncategorized
In translational research today, multi-omics is no longer a concept — it’s an expectation. Genomics and transcriptomics reveal what could happen; proteomics shows what is happening at the protein level; and metabolomics offers the most immediate snapshot of cellular...
by ODWAdmin | Sep 21, 2025 | Uncategorized
Proteolysis-targeting chimeras (PROTACs) have emerged as a transformative approach in drug discovery, offering event-driven protein degradation mechanisms that overcome limitations of traditional occupancy-driven inhibitors. While conventional small-molecule PROTACs...
by ODWAdmin | Sep 19, 2025 | Uncategorized
For food and nutrition researchers, understanding the gut microbiome is paramount to developing next-generation products that promote health. While 16S rRNA sequencing and shotgun metagenomics have provided a census of which microbes live in the gut, they fall short...
