Advanced Microbiome Analysis
Service & Multiomics Integration

The microbiome consists of diverse bacteria which play an important role in immune system development and training, host digestion and nutrition, and protecting against infections. As specific microbiome alterations have been linked to numerous pathologies including cancer, chronic inflammatory diseases, and metabolic dysfunction, researchers have been eager to leverage the microbiome as a source of novel therapeutic and diagnostic discoveries. Panome Bio is creating new angles into this discovery science with a suite of metabolomics tools that allow for an assessment of microbial, host, and exogenous metabolites with a focus on a microbiome’s enzymatic function, and how that could be effecting human physiology.

Panome Bio offers a comprehensive suite of microbiome function analysis tools that bring a focus on bile acids (host and microbial-conjugated) and short chain fatty acids (SCFAs) to our global metabolomics screen, allowing for the greatest discovery potential when studying the role of the microbiome in health and disease. Panome Bio can also offer a multi-omics approach by integrating customer-provided microbiome sequencing and transcriptomics data with our metabolomics. Integration of genomics, transcriptomics, and metabolomics data can be used to identify gene-metabolite relationships, understand metabolic pathways, understand cellular response and mechanism of disease, and discover novel biomarkers and drug targets.

Next-Generation Metabolomics for the Microbiome

• Gain insights into microbial metabolism of bile acids, dietary compounds, flavonoids, steroids, certain lipid-soluble vitamins, and other lipids, allowing for an understanding of food, nutrition, and overall gut health.
• Be informed of general metabolism in a given sample including established energy-generating pathways through evaluation of amino acids, sugars, nucleotides, nucleosides, and energy metabolites, among many others.
• Detect up to 68 primary, secondary, and microbially-conjugated bile acids

Focused Assay: Short Chain Fatty Acids (SCFAs), Ketones, Branched-Chain Amino Acids (BCAAs)

• Understand overall gut microbiome structure, health, and homeostasis and comprehend intestinal barrier function
• Measure up to 18 derivatized SCFAs, ketones, and BCAAs

Sample Requirements

• Most common sample types include fecal samples, urine, serum/plasma and liver, kidney, intestine (small and large), gallbladder, cecum samples.
• Many other sample types can be accommodated.
• Amounts required per assay: 5 mg wet weight of tissue, 30 mg wet weight for fecal samples (2-3 mouse pellets), 50 uL of biofluid, fecal slurry (variable, 30 mg)