Panome Bio’s advanced multi-omic technology offer unparalleled insights for animal model studies, helping you to understand disease mechanisms, evaluate therapeutic interventions, and identify novel biomarkers. Our services provide a comprehensive view of biological systems, from small molecule metabolites to complex proteins, and can integrate these layers for a deeper, more mechanistic understanding.
Identify and characterize specific metabolic changes arising from genetic modifications or disease conditions.
ApoE Knockout Rat Study
14 Sphingolipids and cholesterol-related compounds were increased in both serum and liver, reflecting a broad dysregulation of lipid metabolism associated with ApoE knockout.
Mdr1a knockout rat study
In the liver, specific phosphatidylserine and phosphatidylinositol species containing essential fatty acids were dysregulated in both tissue types, suggesting an interaction between Mdr1a and polyunsaturated fatty acids.
Evaluate therapeutic interventions and dietary impacts
Anti-mPD-1 Treatment in DIO Mice
Integrated pathway analysis revealed dysregulation of Warburg effect analytes that were elevated in DIO mice but decreased with amPD-1 treatment.
Short-Term Dietary Methionine Restriction With High-Fat Diet in Obese Mice
Pathway enrichment analysis of all metabolites revealed differences in HFD-MetR groups related to the citric acid cycle, fatty
acid biosynthesis and metabolism, oxidation of fatty acids, and mitochondrial activity. Especially after 10 days of HFD-MetR, there were strong increases in these pathways and mitochondrial fatty acid oxidation.
Gain Deep Mechanistic Insights with Integrated Multi-Omics
- Combine metabolite, protein, and trascriptional data for a holistic view of your system
- Identify more dysregulated biochemical pathways than with a single data type alone
- Link molecular changes to understand complex regulatory mechanisms
- Uncover critical shifts like the downregulation of energy metabolism pathways (glycolysis, nucleotide metabolism) as nutrient availability changes
Anti-mPD-1 treatment in DIO mice
Integrated network analysis revealed levels of ribose 5-phosphate and transketolase indicated reduced activity of the non-oxidative branch of the pentose phosphate pathway after amPD-1 treatment in DIO mice, an effect not observed in WT mice. This provided a more mechanistic understanding of the observed metabolic changes.
Uncover the Complex Interplay Between Different Biological Molecules
- Mechanism of action clarity: reveal how therapeutic compounds affect molecular pathways across tissues
- Early biomarker discovery: Identify predictive markers of efficacy, toxicity, or disease progression before phenotypic changes occur
- Improved translational relevance: Link findings in preclinical models to human biology with greater confidence
Data Report: Control vs ApoE Knockout Rats
Explore the power of metabolomics to identify metabolic dysregulation associated with ApoE knockout.
Poster: Antitumor and Metabolomic Differences in DIO Mice
Discover differences in tumor inhibition and treatment response between obese and control diet-fed mice.
Data Report: Control vs Mdr1a Knockout Rats
Learn how metabolomics is applied in serum and liver samples to characterize metabolic changes in Mdr1a knockout rats.
Unlock Deeper Insights with Panome Bio
Panome Bio’s Next-Generation Metabolomics enables high-quality detection, helping you save time and resources. Go beyond simple comparisons to explore large cohorts and longitudinal studies. Our advanced platform delivers a global, qualitative view of metabolism, with powerful computational tools to make sense of complex data.
Contact us to start your project.