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How does fructose promote cancer? Untargeted metabolomics connects the dots

Fructose consumption has skyrocketed in recent decades, but could this common sweetener be fueling cancer in unexpected ways? In this webinar, Ronald Fowle-Grider, PhD dives into new research uncovering how fructose indirectly enhances tumor growth—not by acting as a direct fuel, but by altering lipid metabolism in the liver.

Join us as we explore how fructose metabolism in hepatocytes leads to the production of lysophosphatidylcholines (LPCs), which in turn promote cancer cell proliferation. Our discussion will highlight key findings from animal models of melanoma, breast cancer, and cervical cancer, demonstrating how dietary fructose accelerates tumor progression even in the absence of weight gain or insulin resistance. We’ll also examine the potential of targeting ketohexokinase (KHK) as a therapeutic strategy to block this metabolic pathway.