Reveal the Hidden Impact of your Microbiome Research
The gut microbiome plays a key role in regulating digestion, immunity, brain function and metabolism. When this delicate ecosystem is disrupted, such as by antibiotics, metabolic processes can shift dramatically.
Next Generation Metabolomics captures broad and meaningful shifts across a wide range of metabolites, to reveal how changes in the microbiome impact overall health. High-resolution, untargeted approach will deliver uncover hidden imbalances, guide targeted interventions, and accelerate the development of microbiome- focused solutions
In a case study, Panome Bio examined how antibiotic-induced microbiome depletion affects fecal metabolic and enzymatic activity in mice. Using a 14-day antibiotic regimen and controls, fecal samples were analyzed with Next-Generation Metabolomics, revealing microbiome-driven shifts.
Comprehensive Fecal Metabolome Profiling
By identifying over 4200 unique metabolites, including bile acids, as well as polar and non-polar compounds, this analysis reveals the complex chemical dialog of the gut microbiome.
Next Generation Metabolomics profiling delivers unmatched insights into identified compounds, empowering discovery across gut health, liver function and metabolic disease.
Antibiotic treatment drastically reduced crucial lipid and bile acid diversity, reinforcing metabolic diversity as a key biomarker of gut health. These findings underscore the microbiome’s critical role in regulating metabolic homeostasis, impacting lipid signaling, energy metabolism, and host-microbe interactions.
Antibiotics Disrupt Gut Microbiome Metabolic Diversity
A significant reduction in lipid and bile acid diversity was observed, directly reflecting the loss of crucial metabolic activity. This reinforces the microbiome’s central role in maintaining lipid complexity and metabolic balance. In contrast, polar metabolite diversity increased, likely due to the accumulation of compounds normally broken down by bacteria.
Metabolic Pathway Shifts Following Microbiome Depletion
Antibiotic treatment significantly altered 39 metabolic pathways, especially impacting lipid metabolism. While some pathways are upregulated, crucial ones like ceramide biosynthesis are depleted. This loss of ceramides can compromise intestinal barrier integrity and impair cell signaling.
Pathway analysis reveals microbiome depletion disrupts key lipid pathways, elevating host lipids while depleting ceramides.
Panome Bio’s Next-Generation Metabolomics is a powerful technology for capturing important biological shifts in the microbiome and revealing metabolic consequences of microbiome disruption.
Application Note: Revolutionize Your Microbiome Research with Panome Bio’s Advanced Functional Analysis
Gain insights into the microbiome profiling.
Data Report: Microbiome Function Analysis: Three-Armed Approach to Fecal Metabolic Profiling
Explore the effects of the gut microbiome in our detailed report.
Explore your possibilities at Panome Bio and Microbiome Analysis
See how microbiome function can help your research.
Unlock Deeper Insights with Panome Bio
Panome Bio’s Next-Generation Metabolomics enables high-quality detection, helping you save time and resources. Go beyond simple comparisons to explore large cohorts and longitudinal studies. Our advanced platform delivers a global, qualitative view of metabolism, with powerful computational tools to make sense of complex data.
Contact us to start your project.