At Panome Bio, we empower you to optimize your bioprocessing systems through cutting-edge metabolomics, proteomics, and integrated multi-omics analysis. Our comprehensive services provide the detailed molecular insights needed to enhance production, reduce costs, and improve product quality.
Optimize Your Cell Media and Supplementation
- Identify which metabolites are consumed and secreted by cells during growth.
- Detect changes in cell metabolism over time
- Pinpoint potential issues like over-consumption of specific nutrients or the accumulation of undesired byproducts
- Use these insights to improve media formulations and optimize feeding strategies for better growth and yield
Cell growth optimization study
14 Metabolites were observed to have significantly changed in either cells or media. This information provides insight to metabolic activity in the cell culture environment. Media formulation should be improved to promote cell growth.
Spent media
time study
Significant metabolites in media formulation were analyzed and compared across time points. This information facilitates an understanding of the temporal profile of metabolite variation in the media, providing valuable insights into the metabolic dynamics over time. Fed-batch strategies should be optimized as a result.
Refine Bioreactor Conditions
- Analyze metabolic pathway profiles to uncover potential limitations, such as those related to oxygen supply, pH, and more
- Guide adjustments to bioreactor conditions (i.e. increasing mixing) to enhance oxygen availability at critical cell concentrations
Cell growth optimization
study
Mapping metabolic changes in the system with a pathway analysis provided researchers with insights into bioreactor conditions, including an oxygen deficiency.
Gain Deep Mechanistic Insights with Integrated Multi-Omics
- Combine metabolite and protein data for a holistic view of your system
- Identify more affected biochemical pathways than with a single data type alone
- Link molecular changes to understand complex regulatory mechanisms
- Uncover critical shifts like the downregulation of energy metabolism pathways (glycolysis, nucleotide metabolism) as nutrient availability changes
Multi-omic temporal analysis of mammalian cell line
Integrated network analysis provides insight to gene-protein-metabolite interactions. Multi-omic network analysis revealed a progressive downregulation of key energy metabolism pathways as cell culture duration increased, correlating with declining nutrient availability.
Make Informed Adjustments to Your System
- Leverage data-driven insights to make precise adjustments to your bioprocessing workflow
- Understand the metabolic and proteomic responses to culture conditions from your cell line
- Directly impact media composition, supplementation, and bioreactor conditions based on molecular evidence
Data Report: Temporal Analysis of Metabolite Consumption and Production in Cell Culture Media
Explore the power of metabolomics to identify significantly altered metabolites over a time-course study.
Data Report: Integrated Temporal Multi-Omics Analysis of Mammalian Cell Line
Pathway analysis and network integration with metabolomics and proteomics data provide a holistic view of molecular changes occurring in a bioprocessing system.
Application Note: Improved Cell-Cultivated Seafood Production through Untargeted Metabolomics
A customer case study with BlueNalu®: how untargeted metabolomics helped optimize media composition and growth conditions.
Bioprocess Optimization with Panome Bio
Panome Bio’s Multi-Omic capabilities enable high-quality detection, helping you save time and resources. Our advanced platform delivers a global, holistic view of bioprocessing systems, with powerful computational tools to make sense of complex data.
Contact us to start your project.