Next-Generation Metabolomics^®:
True Global Biomarker Discovery

Discover our global lipidomics screen, part of Panome Bio’s Next-Generation Metabolomics^® platform.

Discover our global lipidomics screen, part of Panome Bio’s Next-Generation Metabolomics^® platform. The lipidomics screen can be accessed as a standalone lipidomics offering. Using advanced LC/MS and computational methods, we deliver the highest quality lipidomics data. Our lipid assays offer broad assessment of major biological lipid classes, including ceramides, glycerophosphocholines, and sphingomyelins, amongst others. Our expert team members build intensive biological interpretations from the comprehensive view of lipid metabolism, ensuring you gain the most interpretable insights.

Advantages of Next-Generation Lipidomics

• Panome Bio’s discovery power is not limited by a library or panel.
• The Next-Generation Lipidomics platform uses optimized LC/MS methods and a proprietary computational pipeline that translates raw data into confident identifications of metabolites by matching signals to a comprehensive small molecule database of >175,000 compounds.
• Our algorithms remove non-biological and redundant signals found in untargeted data sets such that we only report known and novel metabolites.
• Data delivered in as little as 4 weeks.

Sample Requirements

• Our platform analyzes diverse sample types from various species with just 50 uL of biofluid, 2 mg of tissue, or 1 million cells.
• We provide clear instructions for sample collection, handling, storage, and shipment.
• We suggest for all sample types flash freeze as quickly as possible following collection to arrest metabolic activity.

Metabolic flux analysis tracks how metabolites move through pathways, revealing critical insights into disease mechanisms and treatment development

Metabolic flux analysis tracks how metabolites move through pathways, revealing critical insights into disease mechanisms and drug development. Using stable isotope labeling experiments, we uncover how fluxes—affected by transcriptional, translational, and post-translational changes—are disrupted in disease states. Our experts will guide you in choosing the ideal stable isotope precursor and designing optimal labeling conditions to maximize your results. Our flux experiments can cover:

• Pentose phosphate pathway
• Tricarboxylic Acid Cycle & Reductive Carboxylation
• Fatty Acid Synthesis & Pyruvate Carboxylase
• Glycolysis
• Bioprocessing

Advantages of our Metabolic Flux Offering

• Metabolic flux information helps researchers understand how compounds are are transformed through pathways. This reveals how systems respond to changes in their environment, treatment, or genetic modifications.
• Helps identify rate-limiting steps in metabolic networks, offering insights for potential therapeutic targets or metabolic engineering.
• Integration with Multi-Omics Data: Complements genomic, transcriptomic, and proteomic data, enabling a more comprehensive understanding of the cellular metabolic state.
• Metabolic flux experiments are not only useful in disease pathogenesis and drug target discovery, it is a crucial concept in bioprocessing. Understanding metabolic flux can significantly impact bioprocessing by enhancing product yield and  optimizing substrate utilization.

Panome Bio is providing metabolic profiling with absolute quantitation with a metabolite panel of over 1,000 metabolites.

Panome Bio offers metabolic profiling with absolute quantitation with a metabolite panel of over 1,000 metabolites. Do you have specific analytes of interest? Panome Bio can also develop custom metabolomics panels to meet your research needs.

Researchers can leverage our expertise and advanced technology to leverage targeted metabolomics as they uncover biomarkers, understand metabolic pathways, and drive personalized medicine without the need for in-house capabilities. This service ensures high accuracy, reproducibility, and minimal sample volume requirements, making it an invaluable resource for advancing scientific and clinical research.

Advantages of Absolute Quantitation in Metabolomics

• Standardized, accurate, and reproducible
• Results are quantified based on internal standards and calibration curves
• Absolute quantitation can be useful for further validation.