Next-Generation Metabolomics^®:
True Global Biomarker Discovery

Discover our global lipidomics screen, part of Panome Bio’s Next-Generation Metabolomics^® platform.

Discover our global lipidomics screen, part of Panome Bio’s Next-Generation Metabolomics^® platform. The lipidomics screen can be accessed as a standalone lipidomics offering. Using advanced LC/MS and computational methods, we deliver the highest quality lipidomics data. Our lipid assays offer broad assessment of major biological lipid classes, including ceramides, glycerophosphocholines, and sphingomyelins, amongst others. Our expert team members build intensive biological interpretations from the comprehensive view of lipid metabolism, ensuring you gain the most interpretable insights.

Advantages of Next-Generation Lipidomics

• Panome Bio’s discovery power is not limited by a library or panel.
• The Next-Generation Lipidomics platform uses optimized LC/MS methods and a proprietary computational pipeline that translates raw data into confident identifications of metabolites by matching signals to a comprehensive small molecule database of >175,000 compounds.
• Our algorithms remove non-biological and redundant signals found in untargeted data sets such that we only report known and novel metabolites.
• Data delivered in as little as 4 weeks.

Sample Requirements

• Our platform analyzes diverse sample types from various species with just 50 uL of biofluid, 2 mg of tissue, or 1 million cells.
• We provide clear instructions for sample collection, handling, storage, and shipment.
• We suggest for all sample types flash freeze as quickly as possible following collection to arrest metabolic activity.

Metabolic flux analysis tracks how metabolites move through pathways, revealing critical insights into disease mechanisms and treatment development

Metabolic flux analysis tracks how metabolites move through pathways, revealing critical insights into disease mechanisms and drug development. Using stable isotope labeling experiments, we uncover how fluxes—affected by transcriptional, translational, and post-translational changes—are disrupted in disease states. Our experts will guide you in choosing the ideal stable isotope precursor and designing optimal labeling conditions to maximize your results. Our flux experiments can cover:

• Pentose phosphate pathway
• Tricarboxylic Acid Cycle & Reductive Carboxylation
• Fatty Acid Synthesis & Pyruvate Carboxylase
• Glycolysis
• Bioprocessing

Advantages of our Metabolic Flux Offering

• Metabolic flux information helps researchers understand how compounds are are transformed through pathways. This reveals how systems respond to changes in their environment, treatment, or genetic modifications.
• Helps identify rate-limiting steps in metabolic networks, offering insights for potential therapeutic targets or metabolic engineering.
• Integration with Multi-Omics Data: Complements genomic, transcriptomic, and proteomic data, enabling a more comprehensive understanding of the cellular metabolic state.
• Metabolic flux experiments are not only useful in disease pathogenesis and drug target discovery, it is a crucial concept in bioprocessing. Understanding metabolic flux can significantly impact bioprocessing by enhancing product yield and  optimizing substrate utilization.

Focused metabolite panels to take research from discovery to validation

Targeted metabolomics is focused on measuring specific set of metabolites within a biological sample. By honing in on these key molecules, researchers can gain valuable insights into metabolic pathways, disease states, and the effects of treatments. Panome Bio’s targeted metabolomics services provide a comprehensive approach to understanding the complex biochemical processes that underlie health and disease.

Panome Bio is providing metabolic profiling with absolute quantitation using a metabolite panel of over 1,000 metabolites

Panome Bio offers metabolic profiling with absolute quantitation with a metabolite panel of over 1,000 metabolites. Do you have specific analytes of interest? Panome Bio can also develop custom metabolomics panels to meet your research needs.
Researchers can leverage our expertise and advanced technology to leverage targeted metabolomics as they uncover biomarkers, understand metabolic pathways, and drive personalized medicine without the need for in-house capabilities. This service ensures high accuracy, reproducibility, and minimal sample volume requirements, making it an invaluable resource for advancing scientific and clinical research.

Advantages of Absolute Quantitation in Metabolomics

• Results are quantified based on internal standards and calibration curves
• Absolute quantitation can be useful for further validation.

Panome Bio Provides Advanced Microbiome Analysis with Next-Generation Metabolomics – Create Insights into Microbiome Function with analysis of Bile Acids, SCFAs, & More

The microbiome consists of diverse bacteria which play an important role in immune system development and training, host digestion and nutrition, and protecting against infections. As specific microbiome alterations have been linked to numerous pathologies including cancer, chronic inflammatory diseases, and metabolic dysfunction, researchers have been eager to leverage the microbiome as a source of novel therapeutic and diagnostic discoveries. Panome Bio is creating new angles into this discovery science with a suite of metabolomics tools that allow for an assessment of microbial, host, and exogenous metabolites with a focus on a microbiome’s enzymatic function, and how that could be effecting human physiology.
 
Panome Bio offers a comprehensive suite of microbiome function analysis tools that bring a focus on bile acids (host and microbial-conjugated) and short chain fatty acids (SCFAs) to our global metabolomics screen, allowing for the greatest discovery potential when studying the role of the microbiome in health and disease. Panome Bio can also offer a multi-omics approach by integrating customer-provided microbiome sequencing and transcriptomics data with our metabolomics. Integration of genomics, transcriptomics, and metabolomics data can be used to identify gene-metabolite relationships, understand metabolic pathways, understand cellular response and mechanism of disease, and discover novel biomarkers and drug targets.