TD2 Oncology accelerates preclinical drug development with a robust suite of in vivo and in vitro tumor model systems and advanced bioanalytical services, designed to generate clinically relevant insights into drug efficacy, immune response, and tumor biology. Our diverse portfolio—including syngeneic, orthotopic, patient-derived xenograft (PDX), humanized mouse, diet-induced obesity, adoptive cell therapy, and cell line-derived xenograft (CDX) models—enables precise assessment of immuno-oncology therapies, targeted agents, and combination treatments. Learn more at td2inc.com
Panome Bio and TD2 Collaboration
Diet Induced Obesity Model Impact on ICI Treatment
One of the major benefits of using diet-induced obesity (DIO) in mouse models for cancer research is that the diet-induced obesity itself can be manipulated to study how this condition can modulate cancer progression. DIO mouse models can help us further elucidate the mechanisms underlying these cancers. Additionally, DIO mouse models can be used to investigate the bi-directional relationship between obesity and cancer including direct tumor growth and the effects of obesity on cancer therapies.
Significant metabolite alterations between treated and untreated DIO and CD mice
DIO mouse models offer the potential to study how diet-induced obesity can modulate the effects of different cancer treatments. It is believed that changes in metabolic factors, such as glucose and fatty acid metabolism, as well as other hormones, may influence the efficacy of treatments. DIO mouse models can help to elucidate these changes, aiding the development of targeted therapies for patients.
- DIO mice showed stronger metabolic response to amPD-1
- Very little similarity between treatment groups
- Multiple metabolites showed differential response in DIO vs CD
Data Report: Multi-Omic Analysis of DIO Mice: Insights into Obesity-Related Pathways
Integrated Data Analysis Report amPD-1 Effects in DIO and WT Mice – Serum Metabolomics + Proteomics Integration Results Metabolomics Data Analysis Report amPD-1 Effects.
Poster: Antitumor and Metabolomic Differences in DIO Mice
Discover differences in tumor inhibition and treatment response between obese and control diet-fed mice.
Multi-Omics in Animal Models
Our services provide a comprehensive view of biological systems, from small molecule metabolites to complex proteins, and can integrate these layers for a deeper, more mechanistic understanding.